Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TARS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TARS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TARS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:101,489,250–101,490,332 | 234.8 kb | Distal (>10kb) Multiome | 422 | |
| chr15:101,615,676–101,616,370 | 108.4 kb | Distal (>10kb) Multiome | 506 | |
| chr15:101,651,697–101,653,159 | 72.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr15:101,723,842–101,725,054 | 52 bp | At TSS Multiome | 957 | |
| chr15:101,726,672–101,726,961 | 2.2 kb | Proximal (<10kb) | 8 |
Genomic view of the TARS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.