Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:33,230,505–33,231,592 | 210.1 kb | Distal (>10kb) Multiome | 232 | |
| chr5:33,297,099–33,298,007 | 143.6 kb | Distal (>10kb) Multiome | 169 | |
| chr5:33,435,570–33,436,185 | 4.8 kb | Proximal (<10kb) | 193 | |
| chr5:33,440,328–33,441,918 | 114 bp | At TSS Multiome | 971 | |
| chr5:33,470,450–33,471,020 | 29.8 kb | Distal (>10kb) Multiome | 151 | |
| chr5:33,482,329–33,482,911 | 41.6 kb | Distal (>10kb) Multiome | 126 | |
| chr5:33,891,468–33,892,881 | 451.3 kb | Distal (>10kb) Multiome HiCAR | 260 | |
| chr5:33,935,991–33,936,950 | 495.3 kb | Distal (>10kb) Multiome HiCAR | 282 | |
| chr5:34,007,535–34,008,720 | 567.1 kb | Distal (>10kb) Multiome HiCAR | 987 |
Genomic view of the TARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.