Transcription factors with Perturb-seq knockdown data for TAPT1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAPT1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAPT1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:16,082,315–16,084,250 | 144.1 kb | Distal (>10kb) Multiome | 441 | |
| chr4:16,224,150–16,224,671 | 2.0 kb | Proximal (<10kb) | 80 | |
| chr4:16,225,728–16,227,508 | 313 bp | At TSS Multiome | 578 | |
| chr4:16,236,282–16,236,915 | 9.6 kb | Proximal (<10kb) | 74 | |
| chr4:16,244,822–16,246,193 | 18.7 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the TAPT1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.