TAPBP

TAP binding protein | NGS17, TAPA, TPN, TPSN

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Biological processes 40 terms

Golgi membrane (GO:0000139)MHC class I peptide loading complex (GO:0042824)MHC class I peptide loading complex (GO:0042824)MHC class I peptide loading complex (GO:0042824)MHC class I protein binding (GO:0042288)MHC class I protein complex binding (GO:0023024)MHC class Ib protein complex assembly (GO:0002398)TAP complex binding (GO:0062061)TAP complex binding (GO:0062061)TAP1 binding (GO:0046978)TAP1 binding (GO:0046978)TAP1 binding (GO:0046978)TAP2 binding (GO:0046979)TAP2 binding (GO:0046979)TAP2 binding (GO:0046979)antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)lumenal side of endoplasmic reticulum membrane (GO:0098553)membrane (GO:0016020)molecular adaptor activity (GO:0060090)peptide antigen assembly with MHC class I protein complex (GO:0002502)peptide antigen assembly with MHC class I protein complex (GO:0002502)peptide antigen binding (GO:0042605)peptide antigen binding (GO:0042605)peptide antigen stabilization (GO:0050823)peptide antigen stabilization (GO:0050823)phagocytic vesicle membrane (GO:0030670)phagocytic vesicle membrane (GO:0030670)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein-containing complex assembly (GO:0065003)regulation of gene expression (GO:0010468)regulation of protein complex stability (GO:0061635)retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating TAPBP 0 TFs

Transcription factors with Perturb-seq knockdown data for TAPBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAPBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TAPBP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAPBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:33,080,635–33,081,087	233.6 kb	Distal (>10kb) Multiome	141
chr6:33,161,505–33,162,100	152.5 kb	Distal (>10kb) Multiome	589
chr6:33,199,801–33,201,289	113.6 kb	Distal (>10kb) Multiome	1049
chr6:33,204,263–33,205,422	109.6 kb	Distal (>10kb) Multiome	762
chr6:33,208,069–33,208,990	105.6 kb	Distal (>10kb) Multiome	858
chr6:33,248,132–33,249,983	65.9 kb	Distal (>10kb) Multiome	961
chr6:33,271,370–33,272,508	42.3 kb	Distal (>10kb) Multiome	1058
chr6:33,276,685–33,277,905	36.8 kb	Distal (>10kb) Multiome	807
chr6:33,288,941–33,289,881	24.8 kb	Distal (>10kb) Multiome	701
chr6:33,297,445–33,300,232	16.4 kb	Distal (>10kb) Multiome	1095
chr6:33,312,436–33,314,207	1.3 kb	Proximal (<10kb) Multiome	795
chr6:33,314,948–33,315,286	870 bp	At TSS	249
chr6:33,317,189–33,318,504	3.7 kb	Proximal (<10kb) Multiome	649
chr6:33,322,636–33,323,832	8.9 kb	Proximal (<10kb) Multiome	941
chr6:33,346,609–33,347,126	32.6 kb	Distal (>10kb) Multiome	37
chr6:33,390,888–33,392,247	77.4 kb	Distal (>10kb) Multiome	993
chr6:33,409,936–33,411,502	96.3 kb	Distal (>10kb) Multiome	977
chr6:33,417,606–33,419,249	104.0 kb	Distal (>10kb) Multiome	973
chr6:33,419,793–33,420,532	106.0 kb	Distal (>10kb) Multiome	162
chr6:33,425,590–33,426,362	111.7 kb	Distal (>10kb) Multiome	665
chr6:33,431,024–33,432,096	117.0 kb	Distal (>10kb) Multiome	337
chr6:33,454,074–33,454,852	140.3 kb	Distal (>10kb) Multiome	906
chr6:33,547,185–33,548,324	233.5 kb	Distal (>10kb) Multiome	155
chr6:33,570,899–33,571,638	257.2 kb	Distal (>10kb) Multiome	755
chr6:33,579,935–33,580,700	266.1 kb	Distal (>10kb) Multiome	639
chr6:33,592,764–33,593,449	278.7 kb	Distal (>10kb) Multiome	224

Genome Browser

Genomic view of the TAPBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.