TAOK1
TAO kinase 1 | FLJ14314, KIAA1361, MAP3K16, MARKK, PSK2, TAO1, hKFC-B, hTAOK1

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of MAPK cascade. Located in several cellular components, including microtubule cytoskeleton; nuclear body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2
Biological processes 46 terms
ATP binding (GO:0005524)ATP binding (GO:0005524)DNA damage response (GO:0006974)alpha-tubulin binding (GO:0043014)beta-tubulin binding (GO:0048487)central nervous system neuron development (GO:0021954)central nervous system neuron development (GO:0021954)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)execution phase of apoptosis (GO:0097194)extracellular exosome (GO:0070062)kinase activity (GO:0016301)kinase activity (GO:0016301)microtubule cytoskeleton (GO:0015630)microtubule cytoskeleton organization (GO:0000226)mitotic G2 DNA damage checkpoint signaling (GO:0007095)mitotic G2 DNA damage checkpoint signaling (GO:0007095)negative regulation of microtubule depolymerization (GO:0007026)neuron cellular homeostasis (GO:0070050)perinuclear region of cytoplasm (GO:0048471)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of stress-activated MAPK cascade (GO:0032874)positive regulation of stress-activated MAPK cascade (GO:0032874)positive regulation of stress-activated MAPK cascade (GO:0032874)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of actin cytoskeleton organization (GO:0032956)regulation of cytoskeleton organization (GO:0051493)regulation of cytoskeleton organization (GO:0051493)regulation of microtubule cytoskeleton organization (GO:0070507)tau protein binding (GO:0048156)tau-protein kinase activity (GO:0050321)transferase activity (GO:0016740)
Expression (TPM)
TAOK1 — as a Regulated Gene

TFs regulating TAOK1 0 TFs

Transcription factors with Perturb-seq knockdown data for TAOK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAOK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TAOK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAOK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:29,148,688–29,149,641 241.4 kb Distal (>10kb) Multiome 709
chr17:29,176,562–29,177,220 213.5 kb Distal (>10kb) Multiome 782
chr17:29,179,268–29,180,802 210.9 kb Distal (>10kb) Multiome 781
chr17:29,292,464–29,294,599 97.6 kb Distal (>10kb) Multiome 1029
chr17:29,369,902–29,370,603 20.2 kb Distal (>10kb) Multiome 305
chr17:29,389,919–29,391,325 44 bp At TSS Multiome 863
chr17:29,566,006–29,569,574 178.3 kb Distal (>10kb) Multiome HiCAR 868
chr17:29,572,746–29,573,303 182.6 kb Distal (>10kb) Multiome 252
chr17:29,588,688–29,590,312 199.3 kb Distal (>10kb) Multiome 590
chr17:29,590,975–29,592,562 201.4 kb Distal (>10kb) Multiome 810
chr17:29,612,906–29,613,942 223.2 kb Distal (>10kb) Multiome 581
chr17:29,614,997–29,616,357 225.3 kb Distal (>10kb) Multiome 389
chr17:29,616,988–29,618,466 227.8 kb Distal (>10kb) Multiome 615
chr17:29,622,374–29,623,287 232.5 kb Distal (>10kb) Multiome 470

Genome Browser

Genomic view of the TAOK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:29,138,688 – 29,633,287
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact