The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for TANK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TANK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TANK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:161,159,952–161,161,374 | 37 bp | At TSS Multiome | 1083 | |
| chr2:161,169,913–161,170,241 | 9.6 kb | Proximal (<10kb) | 33 | |
| chr2:161,237,151–161,239,873 | 78.5 kb | Distal (>10kb) Multiome | 760 | |
| chr2:161,244,441–161,245,204 | 84.4 kb | Distal (>10kb) Multiome | 383 | |
| chr2:161,307,935–161,309,054 | 148.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr2:161,413,932–161,417,535 | 254.3 kb | Distal (>10kb) Multiome | 691 | |
| chr2:161,417,732–161,419,279 | 258.5 kb | Distal (>10kb) Multiome | 374 | |
| chr2:161,422,463–161,424,682 | 263.6 kb | Distal (>10kb) Multiome | 296 | |
| chr2:161,426,467–161,428,505 | 267.8 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the TANK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.