Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TANC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TANC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TANC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:158,744,999–158,745,940 | 223.2 kb | Distal (>10kb) Multiome | 282 | |
| chr2:158,962,928–158,963,450 | 5.2 kb | Proximal (<10kb) | 32 | |
| chr2:158,967,509–158,970,337 | 29 bp | At TSS Multiome | 789 | |
| chr2:158,994,876–158,995,952 | 26.8 kb | Distal (>10kb) Multiome | 432 | |
| chr2:159,030,773–159,031,420 | 62.5 kb | Distal (>10kb) Multiome | 313 | |
| chr2:159,049,902–159,050,747 | 81.8 kb | Distal (>10kb) Multiome | 159 | |
| chr2:159,064,425–159,065,288 | 96.1 kb | Distal (>10kb) Multiome | 323 | |
| chr2:159,211,403–159,212,003 | 243.0 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the TANC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.