Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Is active in mitochondrion. Implicated in combined oxidative phosphorylation deficiency 56. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TAMM41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAMM41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAMM41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:11,591,427–11,591,889 | 255.3 kb | Distal (>10kb) Multiome | 294 | |
| chr3:11,643,590–11,644,257 | 202.9 kb | Distal (>10kb) Multiome | 657 | |
| chr3:11,718,742–11,720,867 | 127.3 kb | Distal (>10kb) Multiome | 845 | |
| chr3:11,770,323–11,771,120 | 76.3 kb | Distal (>10kb) Multiome | 481 | |
| chr3:11,846,284–11,847,247 | 19 bp | At TSS Multiome | 833 | |
| chr3:12,003,835–12,005,168 | 157.5 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the TAMM41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.