Predicted to be involved in positive regulation of cell motility. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TALAM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TALAM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TALAM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,213,383–65,213,853 | 293.8 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 281.8 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 245.6 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 191.7 kb | Distal (>10kb) Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 173.6 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 152.8 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,366,306–65,366,977 | 140.9 kb | Distal (>10kb) Multiome | 309 | |
| chr11:65,381,835–65,382,758 | 125.2 kb | Distal (>10kb) Multiome HiCAR | 984 | |
| chr11:65,386,320–65,387,097 | 120.8 kb | Distal (>10kb) Multiome HiCAR | 757 | |
| chr11:65,416,383–65,417,015 | 90.9 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 88.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 85.0 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 52.2 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 29.8 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 19.6 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 9.8 kb | Proximal (<10kb) Multiome | 1059 | |
| chr11:65,498,911–65,499,611 | 7.8 kb | Proximal (<10kb) | 965 | |
| chr11:65,506,702–65,508,865 | 174 bp | At TSS Multiome | 864 | |
| chr11:65,510,563–65,511,044 | 3.1 kb | Proximal (<10kb) | 352 | |
| chr11:65,524,475–65,525,724 | 17.6 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 33.4 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 39.3 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 46.3 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 62.9 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 65.1 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 66.9 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,575,601–65,576,322 | 68.6 kb | Distal (>10kb) Multiome | 527 | |
| chr11:65,591,808–65,592,698 | 84.8 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 99.7 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 106.8 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 108.1 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 130.7 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 134.7 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 139.9 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 145.3 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 155.6 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 204.8 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 213.2 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 272.6 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 281.0 kb | Distal (>10kb) Multiome | 478 |
Genomic view of the TALAM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.