This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for TAFA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAFA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAFA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:66,971,880–66,972,546 | 1960.4 kb | Distal (>10kb) Multiome HiCAR | 371 | |
| chr3:66,988,564–66,989,611 | 1943.5 kb | Distal (>10kb) Multiome HiCAR | 247 | |
| chr3:66,997,578–66,999,244 | 1934.4 kb | Distal (>10kb) Multiome HiCAR | 661 | |
| chr3:68,931,297–68,933,078 | 57 bp | At TSS Multiome | 419 | |
| chr3:69,012,112–69,014,102 | 81.0 kb | Distal (>10kb) Multiome | 935 | |
| chr3:69,079,501–69,080,755 | 147.8 kb | Distal (>10kb) Multiome | 569 | |
| chr3:69,084,409–69,085,904 | 152.4 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the TAFA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.