TAF7

TATA-box binding protein associated factor 7 | TAFII55, TAF2F

The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.2

Biological processes 45 terms

DNA-binding transcription factor binding (GO:0140297)DNA-templated transcription initiation (GO:0006352)MLL1 complex (GO:0071339)P-TEFb complex binding (GO:0106140)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II preinitiation complex assembly (GO:0051123)RNA polymerase II preinitiation complex assembly (GO:0051123)TFIIH-class transcription factor complex binding (GO:0001097)chromatin organization (GO:0006325)cytoplasm (GO:0005737)histone H3K27me3 reader activity (GO:0061628)histone acetyltransferase binding (GO:0035035)histone acetyltransferase binding (GO:0035035)mRNA transcription by RNA polymerase II (GO:0042789)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of MHC class I biosynthetic process (GO:0045344)negative regulation of MHC class II biosynthetic process (GO:0045347)negative regulation of protein kinase activity (GO:0006469)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear thyroid hormone receptor binding (GO:0046966)nuclear vitamin D receptor binding (GO:0042809)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)regulation of DNA repair (GO:0006282)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)spermine transport (GO:0000296)transcription by RNA polymerase II (GO:0006366)transcription cis-regulatory region binding (GO:0000976)transcription factor TFIID complex (GO:0005669)transcription factor TFIID complex (GO:0005669)transcription factor TFIID complex (GO:0005669)transcription factor TFTC complex (GO:0033276)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating TAF7 0 TFs

Transcription factors with Perturb-seq knockdown data for TAF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TAF7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:141,039,880–141,041,470	279.6 kb	Distal (>10kb) Multiome	682
chr5:141,094,443–141,094,942	226.1 kb	Distal (>10kb) Multiome	336
chr5:141,320,208–141,321,296	76 bp	At TSS Multiome	954
chr5:141,407,865–141,408,477	87.3 kb	Distal (>10kb) Multiome	109
chr5:141,417,522–141,418,139	96.9 kb	Distal (>10kb) Multiome	106
chr5:141,475,524–141,476,908	155.1 kb	Distal (>10kb) Multiome	402
chr5:141,484,493–141,485,507	164.2 kb	Distal (>10kb) Multiome	189
chr5:141,508,593–141,509,337	188.2 kb	Distal (>10kb) Multiome	242
chr5:141,512,198–141,512,900	191.8 kb	Distal (>10kb) Multiome	300
chr5:141,513,616–141,515,069	193.8 kb	Distal (>10kb) Multiome	392
chr5:141,524,502–141,525,311	204.1 kb	Distal (>10kb) Multiome	605
chr5:141,557,658–141,558,135	237.1 kb	Distal (>10kb) Multiome	373
chr5:141,560,663–141,561,120	240.2 kb	Distal (>10kb) Multiome	327
chr5:141,617,831–141,619,550	298.3 kb	Distal (>10kb) Multiome	1037

Genome Browser

Genomic view of the TAF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.