Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TAF6L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF6L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF6L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,508,289–62,508,878 | 262.8 kb | Distal (>10kb) Multiome | 499 | |
| chr11:62,542,658–62,543,488 | 228.4 kb | Distal (>10kb) Multiome | 537 | |
| chr11:62,545,051–62,547,562 | 224.4 kb | Distal (>10kb) Multiome | 889 | |
| chr11:62,553,213–62,553,741 | 218.0 kb | Distal (>10kb) Multiome | 489 | |
| chr11:62,555,905–62,556,742 | 215.1 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 210.7 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 209.4 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 197.4 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 179.6 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 169.5 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 158.5 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 149.3 kb | Distal (>10kb) Multiome | 964 | |
| chr11:62,646,025–62,647,031 | 124.7 kb | Distal (>10kb) Multiome | 815 | |
| chr11:62,652,836–62,653,744 | 118.0 kb | Distal (>10kb) Multiome | 921 | |
| chr11:62,664,567–62,666,291 | 106.2 kb | Distal (>10kb) Multiome | 1020 | |
| chr11:62,671,328–62,672,522 | 99.6 kb | Distal (>10kb) Multiome | 882 | |
| chr11:62,705,543–62,707,930 | 65.1 kb | Distal (>10kb) Multiome | 760 | |
| chr11:62,708,691–62,710,293 | 61.8 kb | Distal (>10kb) Multiome | 531 | |
| chr11:62,726,557–62,728,947 | 43.8 kb | Distal (>10kb) Multiome | 1088 | |
| chr11:62,753,347–62,754,665 | 17.2 kb | Distal (>10kb) Multiome | 696 | |
| chr11:62,761,085–62,762,045 | 9.9 kb | Proximal (<10kb) Multiome | 649 | |
| chr11:62,769,739–62,769,976 | 1.4 kb | Proximal (<10kb) | 303 | |
| chr11:62,770,753–62,772,068 | 56 bp | At TSS Multiome | 885 | |
| chr11:62,786,365–62,787,860 | 15.2 kb | Distal (>10kb) Multiome | 1073 | |
| chr11:62,791,569–62,792,385 | 20.6 kb | Distal (>10kb) Multiome | 805 | |
| chr11:62,804,451–62,807,080 | 34.1 kb | Distal (>10kb) Multiome | 994 | |
| chr11:62,831,037–62,832,904 | 60.6 kb | Distal (>10kb) Multiome | 870 | |
| chr11:62,839,042–62,842,743 | 70.0 kb | Distal (>10kb) Multiome | 1403 | |
| chr11:62,851,028–62,851,955 | 80.1 kb | Distal (>10kb) Multiome | 421 | |
| chr11:62,855,209–62,856,560 | 84.6 kb | Distal (>10kb) Multiome | 1071 | |
| chr11:62,862,252–62,862,948 | 91.3 kb | Distal (>10kb) Multiome | 360 | |
| chr11:62,880,343–62,881,977 | 109.5 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:62,909,033–62,909,985 | 138.0 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the TAF6L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.