TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Transcription factors with Perturb-seq knockdown data for TADA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TADA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TADA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:166,838,839–166,841,323 | 35.5 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:166,872,163–166,872,345 | 3.9 kb | Proximal (<10kb) | 13 | |
| chr1:166,875,665–166,876,831 | 70 bp | At TSS Multiome | 947 | |
| chr1:166,883,947–166,884,647 | 8.2 kb | Proximal (<10kb) Multiome | 218 | |
| chr1:166,920,313–166,921,576 | 44.7 kb | Distal (>10kb) Multiome | 206 | |
| chr1:166,975,212–166,976,080 | 99.4 kb | Distal (>10kb) Multiome | 470 | |
| chr1:167,066,432–167,066,980 | 190.5 kb | Distal (>10kb) Multiome | 430 | |
| chr1:167,121,335–167,122,028 | 245.4 kb | Distal (>10kb) Multiome | 238 | |
| chr1:167,148,291–167,148,891 | 272.3 kb | Distal (>10kb) Multiome | 99 | |
| chr1:167,165,942–167,166,725 | 290.2 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the TADA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.