Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TACC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TACC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TACC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:120,948,941–120,949,508 | 1070.7 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr10:121,891,008–121,891,561 | 128.4 kb | Distal (>10kb) Multiome | 140 | |
| chr10:121,927,427–121,928,651 | 91.7 kb | Distal (>10kb) Multiome | 904 | |
| chr10:121,974,336–121,975,594 | 44.6 kb | Distal (>10kb) Multiome | 875 | |
| chr10:122,112,641–122,114,050 | 93.2 kb | Distal (>10kb) Multiome | 855 | |
| chr10:122,162,689–122,164,583 | 143.7 kb | Distal (>10kb) Multiome | 396 | |
| chr10:122,342,331–122,342,835 | 322.8 kb | Distal (>10kb) Multiome | 161 | |
| chr10:122,373,966–122,375,595 | 354.9 kb | Distal (>10kb) Multiome | 792 |
Genomic view of the TACC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.