This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for SYT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,281,385–61,282,193 | 299.4 kb | Distal (>10kb) Multiome | 231 | |
| chr11:61,294,197–61,295,784 | 286.1 kb | Distal (>10kb) Multiome | 761 | |
| chr11:61,332,596–61,333,687 | 248.0 kb | Distal (>10kb) Multiome | 897 | |
| chr11:61,361,602–61,362,481 | 219.0 kb | Distal (>10kb) Multiome | 905 | |
| chr11:61,392,209–61,392,929 | 188.5 kb | Distal (>10kb) Multiome | 800 | |
| chr11:61,429,326–61,430,423 | 151.2 kb | Distal (>10kb) Multiome | 975 | |
| chr11:61,508,087–61,510,095 | 71.6 kb | Distal (>10kb) Multiome | 740 | |
| chr11:61,567,110–61,568,033 | 13.5 kb | Distal (>10kb) Multiome | 1078 | |
| chr11:61,580,454–61,581,871 | 195 bp | At TSS Multiome | 760 | |
| chr11:61,587,343–61,588,726 | 7.2 kb | Proximal (<10kb) Multiome | 271 | |
| chr11:61,680,168–61,680,631 | 99.2 kb | Distal (>10kb) Multiome | 532 | |
| chr11:61,752,190–61,753,041 | 171.5 kb | Distal (>10kb) Multiome | 329 | |
| chr11:61,777,258–61,777,759 | 196.3 kb | Distal (>10kb) Multiome | 149 | |
| chr11:61,792,046–61,793,394 | 211.7 kb | Distal (>10kb) Multiome | 896 | |
| chr11:61,814,541–61,817,407 | 234.1 kb | Distal (>10kb) Multiome | 1128 | |
| chr11:61,827,285–61,829,337 | 246.8 kb | Distal (>10kb) Multiome | 728 | |
| chr11:61,871,019–61,871,621 | 290.2 kb | Distal (>10kb) Multiome | 443 |
Genomic view of the SYT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.