Involved in substantia nigra development. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:109,213,499–109,214,619 | 252.7 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 236.6 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,240,604–109,241,116 | 225.5 kb | Distal (>10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 217.0 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 202.8 kb | Distal (>10kb) Multiome | 767 | |
| chr1:109,282,693–109,283,858 | 183.3 kb | Distal (>10kb) Multiome | 850 | |
| chr1:109,397,369–109,398,671 | 68.5 kb | Distal (>10kb) Multiome | 654 | |
| chr1:109,425,842–109,427,054 | 40.0 kb | Distal (>10kb) Multiome | 922 | |
| chr1:109,466,294–109,467,385 | 77 bp | At TSS Multiome | 452 | |
| chr1:109,483,147–109,484,806 | 17.4 kb | Distal (>10kb) Multiome | 1031 | |
| chr1:109,493,695–109,494,597 | 27.6 kb | Distal (>10kb) Multiome | 842 | |
| chr1:109,498,180–109,498,608 | 31.9 kb | Distal (>10kb) Multiome | 178 | |
| chr1:109,509,196–109,510,011 | 43.1 kb | Distal (>10kb) Multiome | 448 | |
| chr1:109,532,157–109,533,159 | 66.2 kb | Distal (>10kb) Multiome | 517 | |
| chr1:109,548,385–109,549,096 | 82.1 kb | Distal (>10kb) Multiome | 855 | |
| chr1:109,619,434–109,621,357 | 153.2 kb | Distal (>10kb) Multiome | 814 | |
| chr1:109,643,342–109,643,856 | 177.0 kb | Distal (>10kb) Multiome | 470 | |
| chr1:109,655,698–109,656,566 | 189.6 kb | Distal (>10kb) Multiome | 707 | |
| chr1:109,667,812–109,668,362 | 201.5 kb | Distal (>10kb) Multiome | 287 | |
| chr1:109,739,695–109,740,873 | 273.8 kb | Distal (>10kb) Multiome | 633 |
Genomic view of the SYPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.