This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for SYNGR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNGR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNGR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:77,915,676–77,916,129 | 252.7 kb | Distal (>10kb) Multiome | 105 | |
| chr17:77,935,380–77,936,363 | 232.7 kb | Distal (>10kb) Multiome | 171 | |
| chr17:77,957,585–77,959,667 | 210.1 kb | Distal (>10kb) Multiome | 1117 | |
| chr17:78,127,361–78,129,338 | 39.8 kb | Distal (>10kb) Multiome | 909 | |
| chr17:78,140,136–78,141,130 | 28.0 kb | Distal (>10kb) Multiome | 594 | |
| chr17:78,168,117–78,169,078 | 75 bp | At TSS Multiome | 738 | |
| chr17:78,169,349–78,169,872 | 769 bp | At TSS | 342 | |
| chr17:78,176,643–78,176,837 | 8.1 kb | Proximal (<10kb) | 342 | |
| chr17:78,186,463–78,187,739 | 18.6 kb | Distal (>10kb) Multiome | 1021 | |
| chr17:78,213,978–78,214,702 | 45.6 kb | Distal (>10kb) Multiome | 902 | |
| chr17:78,231,715–78,232,315 | 63.5 kb | Distal (>10kb) Multiome | 147 | |
| chr17:78,250,689–78,251,651 | 82.5 kb | Distal (>10kb) Multiome | 714 | |
| chr17:78,254,178–78,254,892 | 85.9 kb | Distal (>10kb) Multiome | 860 | |
| chr17:78,270,255–78,273,257 | 103.9 kb | Distal (>10kb) Multiome | 667 | |
| chr17:78,278,089–78,278,902 | 109.9 kb | Distal (>10kb) Multiome | 225 | |
| chr17:78,313,762–78,314,579 | 145.7 kb | Distal (>10kb) Multiome | 636 | |
| chr17:78,341,604–78,342,374 | 173.4 kb | Distal (>10kb) Multiome | 423 | |
| chr17:78,351,461–78,352,240 | 183.2 kb | Distal (>10kb) Multiome | 383 | |
| chr17:78,352,598–78,353,774 | 184.5 kb | Distal (>10kb) Multiome | 687 | |
| chr17:78,356,201–78,356,710 | 187.9 kb | Distal (>10kb) Multiome | 319 | |
| chr17:78,358,869–78,361,525 | 191.7 kb | Distal (>10kb) Multiome | 898 | |
| chr17:78,365,478–78,366,101 | 197.3 kb | Distal (>10kb) Multiome | 305 | |
| chr17:78,378,324–78,379,091 | 210.0 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the SYNGR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.