This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SYF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:24,929,080–24,930,934 | 302.1 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr1:24,931,551–24,932,717 | 300.1 kb | Distal (>10kb) Multiome | 362 | |
| chr1:25,232,067–25,232,905 | 50 bp | At TSS Multiome | 757 | |
| chr1:25,233,146–25,233,599 | 834 bp | At TSS Multiome | 493 | |
| chr1:25,239,634–25,240,475 | 7.4 kb | Proximal (<10kb) Multiome | 897 | |
| chr1:25,246,452–25,248,229 | 15.1 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:25,338,116–25,338,949 | 105.9 kb | Distal (>10kb) Multiome | 803 | |
| chr1:25,429,935–25,431,604 | 197.8 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the SYF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.