Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SWT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SWT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SWT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:184,754,064–184,755,736 | 402.5 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr1:184,905,067–184,906,277 | 251.8 kb | Distal (>10kb) Multiome | 314 | |
| chr1:184,973,585–184,974,868 | 183.3 kb | Distal (>10kb) Multiome | 731 | |
| chr1:185,044,828–185,046,417 | 112.1 kb | Distal (>10kb) Multiome | 816 | |
| chr1:185,156,218–185,158,419 | 314 bp | At TSS Multiome | 949 | |
| chr1:185,315,737–185,318,408 | 160.0 kb | Distal (>10kb) Multiome | 1078 |
Genomic view of the SWT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.