Enables cation binding activity; histone H3K9 methyltransferase activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SUV39H2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUV39H2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUV39H2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:14,603,765–14,604,803 | 274.5 kb | Distal (>10kb) Multiome | 535 | |
| chr10:14,649,147–14,650,080 | 229.3 kb | Distal (>10kb) Multiome | 36 | |
| chr10:14,737,931–14,738,710 | 140.5 kb | Distal (>10kb) Multiome | 67 | |
| chr10:14,837,437–14,839,368 | 40.7 kb | Distal (>10kb) Multiome | 908 | |
| chr10:14,877,852–14,879,824 | 120 bp | At TSS Multiome | 977 | |
| chr10:14,952,697–14,954,554 | 74.3 kb | Distal (>10kb) Multiome | 1101 | |
| chr10:14,959,013–14,960,243 | 80.7 kb | Distal (>10kb) Multiome | 879 | |
| chr10:15,088,358–15,089,070 | 209.9 kb | Distal (>10kb) Multiome | 622 | |
| chr10:15,096,597–15,098,027 | 218.4 kb | Distal (>10kb) Multiome | 949 | |
| chr10:15,167,406–15,169,756 | 290.0 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the SUV39H2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.