Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SUPT3H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUPT3H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUPT3H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,469,799–44,470,296 | 908.0 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr6:44,475,548–44,476,402 | 902.0 kb | Distal (>10kb) Multiome HiCAR | 587 | |
| chr6:44,655,058–44,656,097 | 722.4 kb | Distal (>10kb) Multiome HiCAR | 531 | |
| chr6:45,377,101–45,378,585 | 25 bp | At TSS Multiome | 1059 | |
| chr6:45,421,479–45,424,366 | 45.3 kb | Distal (>10kb) Multiome | 638 |
Genomic view of the SUPT3H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.