Transcription factors with Perturb-seq knockdown data for SUNO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUNO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUNO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:33,621,458–33,623,467 | 284.4 kb | Distal (>10kb) Multiome | 384 | |
| chr19:33,777,882–33,778,531 | 128.2 kb | Distal (>10kb) Multiome | 668 | |
| chr19:33,795,218–33,798,802 | 110.7 kb | Distal (>10kb) Multiome | 887 | |
| chr19:33,819,821–33,820,728 | 86.1 kb | Distal (>10kb) Multiome | 512 | |
| chr19:33,905,451–33,907,250 | 32 bp | At TSS Multiome | 371 | |
| chr19:33,958,246–33,958,760 | 52.1 kb | Distal (>10kb) Multiome | 13 | |
| chr19:34,134,218–34,135,012 | 228.2 kb | Distal (>10kb) Multiome HiCAR | 833 | |
| chr19:34,171,846–34,173,343 | 266.0 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the SUNO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.