This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]
Transcription factors with Perturb-seq knockdown data for SUN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:321,971–322,829 | 494.3 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr7:332,380–333,313 | 483.8 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr7:518,879–521,101 | 296.5 kb | Distal (>10kb) Multiome | 523 | |
| chr7:726,194–727,335 | 89.9 kb | Distal (>10kb) Multiome | 891 | |
| chr7:815,511–817,550 | 298 bp | At TSS Multiome | 640 | |
| chr7:875,946–877,507 | 59.9 kb | Distal (>10kb) Multiome | 918 | |
| chr7:901,112–902,113 | 85.1 kb | Distal (>10kb) Multiome | 376 | |
| chr7:953,606–955,017 | 137.9 kb | Distal (>10kb) Multiome | 482 | |
| chr7:974,909–975,889 | 158.9 kb | Distal (>10kb) Multiome | 860 | |
| chr7:992,812–993,637 | 176.7 kb | Distal (>10kb) Multiome | 824 | |
| chr7:1,028,063–1,028,589 | 211.7 kb | Distal (>10kb) Multiome | 503 | |
| chr7:1,044,102–1,045,027 | 227.9 kb | Distal (>10kb) Multiome | 715 | |
| chr7:1,059,302–1,060,226 | 243.1 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the SUN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.