This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SUMO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUMO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUMO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,893,600–74,894,183 | 289.2 kb | Distal (>10kb) Multiome | 189 | |
| chr17:74,923,198–74,923,804 | 259.4 kb | Distal (>10kb) Multiome | 543 | |
| chr17:74,972,019–74,973,116 | 210.2 kb | Distal (>10kb) Multiome | 607 | |
| chr17:74,982,006–74,982,936 | 200.6 kb | Distal (>10kb) Multiome | 952 | |
| chr17:74,987,081–74,988,770 | 195.3 kb | Distal (>10kb) Multiome | 702 | |
| chr17:75,012,158–75,013,285 | 170.2 kb | Distal (>10kb) Multiome | 1058 | |
| chr17:75,033,550–75,035,757 | 147.8 kb | Distal (>10kb) Multiome | 1228 | |
| chr17:75,046,451–75,047,855 | 135.9 kb | Distal (>10kb) Multiome | 961 | |
| chr17:75,087,344–75,088,429 | 95.2 kb | Distal (>10kb) Multiome | 717 | |
| chr17:75,089,013–75,089,866 | 93.6 kb | Distal (>10kb) Multiome | 406 | |
| chr17:75,104,838–75,106,094 | 77.2 kb | Distal (>10kb) Multiome | 454 | |
| chr17:75,109,401–75,110,734 | 73.0 kb | Distal (>10kb) Multiome | 762 | |
| chr17:75,113,757–75,114,535 | 68.8 kb | Distal (>10kb) Multiome | 585 | |
| chr17:75,130,577–75,132,090 | 51.3 kb | Distal (>10kb) Multiome | 990 | |
| chr17:75,153,354–75,155,273 | 28.4 kb | Distal (>10kb) Multiome | 993 | |
| chr17:75,182,199–75,183,441 | 58 bp | At TSS Multiome | 908 | |
| chr17:75,205,060–75,205,995 | 22.5 kb | Distal (>10kb) Multiome | 975 | |
| chr17:75,240,373–75,240,941 | 57.7 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 78.8 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 88.3 kb | Distal (>10kb) Multiome | 946 | |
| chr17:75,288,761–75,289,874 | 106.6 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,346,809–75,347,324 | 164.2 kb | Distal (>10kb) Multiome | 265 | |
| chr17:75,393,479–75,394,300 | 211.0 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 222.8 kb | Distal (>10kb) Multiome | 917 | |
| chr17:75,456,149–75,457,264 | 273.6 kb | Distal (>10kb) Multiome | 865 | |
| chr17:75,481,081–75,481,680 | 298.4 kb | Distal (>10kb) Multiome | 64 |
Genomic view of the SUMO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.