This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SULF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SULF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SULF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:69,459,914–69,460,100 | 6.7 kb | Proximal (<10kb) | 13 | |
| chr8:69,460,206–69,460,696 | 6.1 kb | Proximal (<10kb) | 117 | |
| chr8:69,463,275–69,463,563 | 3.3 kb | Proximal (<10kb) | 41 | |
| chr8:69,463,838–69,464,134 | 2.7 kb | Proximal (<10kb) | 27 | |
| chr8:69,466,146–69,467,187 | 125 bp | At TSS Multiome | 251 | |
| chr8:69,710,813–69,711,725 | 244.5 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the SULF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.