The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for STYX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STYX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STYX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,551,688–52,554,284 | 177.5 kb | Distal (>10kb) Multiome | 899 | |
| chr14:52,694,713–52,696,105 | 34.4 kb | Distal (>10kb) Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 23.0 kb | Distal (>10kb) Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 76 bp | At TSS Multiome | 803 | |
| chr14:52,733,910–52,734,123 | 3.7 kb | Proximal (<10kb) | 5 | |
| chr14:52,790,881–52,792,384 | 61.5 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:52,827,263–52,828,172 | 97.5 kb | Distal (>10kb) Multiome | 103 | |
| chr14:52,835,079–52,835,883 | 105.2 kb | Distal (>10kb) Multiome | 369 | |
| chr14:52,852,332–52,854,201 | 123.1 kb | Distal (>10kb) Multiome | 475 | |
| chr14:52,950,305–52,952,252 | 221.1 kb | Distal (>10kb) Multiome | 746 | |
| chr14:54,366,777–54,367,506 | 1636.9 kb | Distal (>10kb) Multiome HiCAR | 393 |
Genomic view of the STYX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.