The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:130,716,209–130,717,026 | 122.8 kb | Distal (>10kb) Multiome | 196 | |
| chr12:130,818,705–130,819,446 | 20.1 kb | Distal (>10kb) Multiome | 387 | |
| chr12:130,838,421–130,839,832 | 32 bp | At TSS Multiome | 714 | |
| chr12:130,853,443–130,853,949 | 14.5 kb | Distal (>10kb) Multiome | 118 | |
| chr12:130,870,687–130,872,721 | 32.7 kb | Distal (>10kb) Multiome | 904 | |
| chr12:131,104,577–131,105,161 | 265.6 kb | Distal (>10kb) Multiome | 341 |
Genomic view of the STX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.