This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for STX18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:4,247,950–4,248,717 | 293.7 kb | Distal (>10kb) Multiome | 853 | |
| chr4:4,289,645–4,290,743 | 251.8 kb | Distal (>10kb) Multiome | 779 | |
| chr4:4,386,227–4,387,401 | 155.5 kb | Distal (>10kb) Multiome | 247 | |
| chr4:4,541,695–4,542,519 | 56 bp | At TSS Multiome | 1129 | |
| chr4:4,574,736–4,575,902 | 33.4 kb | Distal (>10kb) Multiome | 433 | |
| chr4:4,641,708–4,642,896 | 100.4 kb | Distal (>10kb) Multiome | 338 | |
| chr4:4,667,130–4,668,212 | 125.7 kb | Distal (>10kb) Multiome | 171 | |
| chr4:4,673,012–4,673,515 | 131.2 kb | Distal (>10kb) Multiome | 164 | |
| chr4:4,763,386–4,764,175 | 221.6 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the STX18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.