STUB1
STIP1 homology and U-box containing protein 1 | CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1

This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

Member of: DE-1 DE-1.13
Biological processes 116 terms
ERAD pathway (GO:0036503)ERBB2 signaling pathway (GO:0038128)G protein-coupled receptor binding (GO:0001664)Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)Hsp90 protein binding (GO:0051879)MAPK cascade (GO:0000165)MAPK cascade (GO:0000165)R-SMAD binding (GO:0070412)SMAD binding (GO:0046332)TPR domain binding (GO:0030911)Z disc (GO:0030018)Z disc (GO:0030018)cellular response to heat (GO:0034605)cellular response to heat (GO:0034605)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to misfolded protein (GO:0071218)cellular response to misfolded protein (GO:0071218)cellular response to misfolded protein (GO:0071218)cellular response to stress (GO:0033554)chaperone-mediated autophagy (GO:0061684)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum unfolded protein response (GO:0030968)enzyme binding (GO:0019899)heat shock protein binding (GO:0031072)kinase binding (GO:0019900)misfolded protein binding (GO:0051787)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of apoptotic process (GO:0043066)negative regulation of cardiac muscle hypertrophy (GO:0010614)negative regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035359)negative regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035359)negative regulation of smooth muscle cell apoptotic process (GO:0034392)negative regulation of smooth muscle cell apoptotic process (GO:0034392)negative regulation of smooth muscle cell apoptotic process (GO:0034392)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of vascular associated smooth muscle contraction (GO:1904694)nuclear inclusion body (GO:0042405)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of ERAD pathway (GO:1904294)positive regulation of chaperone-mediated protein complex assembly (GO:0090035)positive regulation of mitophagy (GO:1901526)positive regulation of mitophagy (GO:1901526)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein ubiquitination (GO:0031398)positive regulation of protein ubiquitination (GO:0031398)positive regulation of proteolysis (GO:0045862)positive regulation of proteolysis (GO:0045862)positive regulation of smooth muscle cell apoptotic process (GO:0034393)positive regulation of smooth muscle cell apoptotic process (GO:0034393)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K63-linked ubiquitination (GO:0070534)protein autoubiquitination (GO:0051865)protein binding (GO:0005515)protein catabolic process (GO:0030163)protein folding chaperone complex (GO:0101031)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein monoubiquitination (GO:0006513)protein polyubiquitination (GO:0000209)protein polyubiquitination (GO:0000209)protein polyubiquitination (GO:0000209)protein quality control for misfolded or incompletely synthesized proteins (GO:0006515)protein quality control for misfolded or incompletely synthesized proteins (GO:0006515)protein quality control for misfolded or incompletely synthesized proteins (GO:0006515)protein stabilization (GO:0050821)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)protein-macromolecule adaptor activity (GO:0030674)regulation of glucocorticoid metabolic process (GO:0031943)regulation of protein stability (GO:0031647)response to ischemia (GO:0002931)response to ischemia (GO:0002931)signal transduction (GO:0007165)tau protein binding (GO:0048156)ubiquitin conjugating enzyme complex (GO:0031371)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-ubiquitin ligase activity (GO:0034450)ubiquitin-ubiquitin ligase activity (GO:0034450)
Expression (TPM)
STUB1 — as a Regulated Gene

TFs regulating STUB1 0 TFs

Transcription factors with Perturb-seq knockdown data for STUB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STUB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to STUB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STUB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:380,836–382,614 298.4 kb Distal (>10kb) Multiome 634
chr16:383,438–384,218 296.6 kb Distal (>10kb) Multiome 342
chr16:396,893–397,640 282.9 kb Distal (>10kb) Multiome 496
chr16:401,380–402,199 278.6 kb Distal (>10kb) Multiome 818
chr16:424,888–426,136 254.8 kb Distal (>10kb) Multiome 752
chr16:483,333–484,000 196.7 kb Distal (>10kb) Multiome 143
chr16:526,749–528,601 152.8 kb Distal (>10kb) Multiome 811
chr16:569,530–570,338 110.6 kb Distal (>10kb) Multiome 492
chr16:578,896–579,353 101.3 kb Distal (>10kb) Multiome 511
chr16:588,593–590,724 90.5 kb Distal (>10kb) Multiome 853
chr16:635,900–638,127 44.1 kb Distal (>10kb) Multiome 1021
chr16:641,491–643,007 38.5 kb Distal (>10kb) Multiome 856
chr16:648,795–649,829 31.1 kb Distal (>10kb) Multiome 862
chr16:660,457–661,656 19.5 kb Distal (>10kb) Multiome 456
chr16:667,633–668,442 12.4 kb Distal (>10kb) Multiome 838
chr16:678,847–681,585 379 bp At TSS Multiome 803
chr16:683,618–684,859 4.0 kb Proximal (<10kb) Multiome 701
chr16:690,350–690,560 9.9 kb Proximal (<10kb) 852
chr16:694,897–695,485 15.0 kb Distal (>10kb) Multiome 390
chr16:705,242–706,468 25.6 kb Distal (>10kb) Multiome 248
chr16:714,577–716,048 34.7 kb Distal (>10kb) Multiome 555
chr16:720,434–721,963 41.0 kb Distal (>10kb) Multiome 966
chr16:726,310–729,144 46.6 kb Distal (>10kb) Multiome 736
chr16:740,359–741,596 60.7 kb Distal (>10kb) Multiome 897
chr16:787,564–789,160 108.1 kb Distal (>10kb) Multiome 635
chr16:807,352–808,044 127.4 kb Distal (>10kb) Multiome 600
chr16:813,330–813,960 133.4 kb Distal (>10kb) Multiome 325
chr16:970,016–971,733 290.6 kb Distal (>10kb) Multiome 800

Genome Browser

Genomic view of the STUB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:370,836 – 981,733
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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