The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for STT3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STT3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STT3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:31,294,792–31,295,861 | 237.3 kb | Distal (>10kb) Multiome | 199 | |
| chr3:31,442,406–31,443,327 | 89.8 kb | Distal (>10kb) Multiome | 150 | |
| chr3:31,531,653–31,533,940 | 144 bp | At TSS Multiome | 1131 | |
| chr3:31,561,940–31,563,982 | 30.0 kb | Distal (>10kb) Multiome | 213 | |
| chr3:31,695,363–31,696,361 | 163.2 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the STT3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.