Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STRN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:46,471,149–46,471,898 | 274.3 kb | Distal (>10kb) Multiome | 339 | |
| chr19:46,495,489–46,496,206 | 249.9 kb | Distal (>10kb) Multiome | 177 | |
| chr19:46,587,845–46,588,467 | 157.7 kb | Distal (>10kb) Multiome | 21 | |
| chr19:46,600,411–46,601,577 | 144.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr19:46,633,826–46,635,061 | 111.5 kb | Distal (>10kb) Multiome | 365 | |
| chr19:46,638,437–46,639,929 | 106.8 kb | Distal (>10kb) Multiome | 741 | |
| chr19:46,659,987–46,662,280 | 84.5 kb | Distal (>10kb) Multiome | 691 | |
| chr19:46,696,773–46,698,048 | 48.3 kb | Distal (>10kb) Multiome | 408 | |
| chr19:46,713,710–46,714,718 | 31.7 kb | Distal (>10kb) Multiome | 566 | |
| chr19:46,716,676–46,717,696 | 28.7 kb | Distal (>10kb) Multiome | 487 | |
| chr19:46,745,601–46,746,962 | 585 bp | At TSS Multiome | 561 | |
| chr19:46,787,215–46,789,013 | 42.8 kb | Distal (>10kb) Multiome | 944 | |
| chr19:46,850,211–46,851,336 | 105.0 kb | Distal (>10kb) Multiome | 946 | |
| chr19:46,855,920–46,856,711 | 110.4 kb | Distal (>10kb) Multiome | 610 | |
| chr19:46,859,815–46,861,611 | 114.5 kb | Distal (>10kb) Multiome | 1061 | |
| chr19:47,019,502–47,020,076 | 273.9 kb | Distal (>10kb) Multiome | 188 | |
| chr19:47,035,599–47,036,293 | 290.2 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the STRN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.