Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium and spliceosomal snRNP assembly. Acts upstream of with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STRAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,768,991–14,772,177 | 1112.6 kb | Distal (>10kb) Multiome HiCAR | 1151 | |
| chr12:15,175,208–15,176,152 | 706.7 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr12:15,637,045–15,638,446 | 244.5 kb | Distal (>10kb) Multiome | 168 | |
| chr12:15,788,278–15,790,322 | 92.9 kb | Distal (>10kb) Multiome | 987 | |
| chr12:15,874,155–15,874,533 | 7.9 kb | Proximal (<10kb) | 7 | |
| chr12:15,881,783–15,883,039 | 37 bp | At TSS Multiome | 910 | |
| chr12:15,910,800–15,911,739 | 28.9 kb | Distal (>10kb) Multiome | 788 | |
| chr12:16,112,192–16,113,482 | 230.5 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the STRAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.