Transcription factors with Perturb-seq knockdown data for STPG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STPG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STPG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:97,910,946–97,912,055 | 231.8 kb | Distal (>10kb) Multiome | 180 | |
| chr4:97,957,479–97,958,328 | 185.7 kb | Distal (>10kb) Multiome | 122 | |
| chr4:98,142,736–98,143,939 | 70 bp | At TSS Multiome | 658 | |
| chr4:98,260,090–98,262,366 | 117.8 kb | Distal (>10kb) Multiome | 990 |
Genomic view of the STPG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.