Enables protein serine/threonine kinase activity. Involved in spermatogenesis. Predicted to be located in manchette. Predicted to be active in nucleus. Implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STK33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:8,328,690–8,329,408 | 265.2 kb | Distal (>10kb) Multiome | 403 | |
| chr11:8,593,749–8,594,754 | 54 bp | At TSS Multiome | 587 | |
| chr11:8,596,637–8,596,917 | 2.6 kb | Proximal (<10kb) | 45 | |
| chr11:8,604,078–8,604,294 | 9.8 kb | Proximal (<10kb) | 202 | |
| chr11:8,671,011–8,671,925 | 77.2 kb | Distal (>10kb) Multiome | 223 | |
| chr11:8,682,170–8,683,291 | 88.5 kb | Distal (>10kb) Multiome | 956 | |
| chr11:8,687,635–8,689,327 | 94.8 kb | Distal (>10kb) Multiome | 1023 | |
| chr11:8,700,857–8,701,532 | 107.1 kb | Distal (>10kb) Multiome | 216 | |
| chr11:8,713,673–8,714,258 | 119.7 kb | Distal (>10kb) Multiome | 102 | |
| chr11:8,800,375–8,801,511 | 206.8 kb | Distal (>10kb) Multiome | 167 | |
| chr11:8,810,380–8,811,275 | 216.5 kb | Distal (>10kb) Multiome | 360 | |
| chr11:8,813,629–8,814,688 | 219.6 kb | Distal (>10kb) Multiome | 380 | |
| chr11:8,870,357–8,871,640 | 276.7 kb | Distal (>10kb) Multiome | 506 |
Genomic view of the STK33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.