STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Transcription factors with Perturb-seq knockdown data for STIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,888,171–63,888,861 | 297.6 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 276.2 kb | Distal (>10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 266.7 kb | Distal (>10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 247.4 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 211.6 kb | Distal (>10kb) Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 199.6 kb | Distal (>10kb) Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 186.7 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 157.5 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 19.9 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,181,606–64,181,869 | 4.3 kb | Proximal (<10kb) | 462 | |
| chr11:64,184,927–64,186,817 | 237 bp | At TSS Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 40.0 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 44.3 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 48.3 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 55.1 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 60.9 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 65.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 83.9 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 85.4 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 99.6 kb | Distal (>10kb) Multiome | 807 | |
| chr11:64,300,129–64,301,268 | 114.9 kb | Distal (>10kb) Multiome | 591 | |
| chr11:64,304,032–64,307,072 | 120.2 kb | Distal (>10kb) Multiome | 994 | |
| chr11:64,316,954–64,319,418 | 132.9 kb | Distal (>10kb) Multiome | 1039 | |
| chr11:64,340,711–64,341,211 | 154.8 kb | Distal (>10kb) Multiome | 212 | |
| chr11:64,342,083–64,343,227 | 156.5 kb | Distal (>10kb) Multiome | 543 | |
| chr11:64,358,792–64,359,751 | 173.0 kb | Distal (>10kb) Multiome | 577 | |
| chr11:64,448,870–64,449,995 | 262.8 kb | Distal (>10kb) Multiome | 490 |
Genomic view of the STIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.