While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for STEEP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STEEP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STEEP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:119,273,185–119,274,073 | 291.7 kb | Distal (>10kb) Multiome | 148 | |
| chrX:119,399,020–119,399,773 | 165.9 kb | Distal (>10kb) Multiome | 440 | |
| chrX:119,468,031–119,469,511 | 97.0 kb | Distal (>10kb) Multiome | 762 | |
| chrX:119,565,311–119,565,575 | at TSS | At TSS | 451 | |
| chrX:119,573,862–119,575,243 | 9.2 kb | Proximal (<10kb) Multiome | 734 | |
| chrX:119,605,775–119,606,635 | 41.1 kb | Distal (>10kb) Multiome | 518 | |
| chrX:119,692,568–119,693,792 | 128.0 kb | Distal (>10kb) Multiome | 595 | |
| chrX:119,757,760–119,759,432 | 192.9 kb | Distal (>10kb) Multiome | 507 | |
| chrX:119,791,353–119,792,197 | 226.4 kb | Distal (>10kb) Multiome | 699 | |
| chrX:119,852,659–119,853,400 | 287.7 kb | Distal (>10kb) Multiome | 612 |
Genomic view of the STEEP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.