This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for STEAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STEAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STEAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,155,495–119,157,277 | 67.9 kb | Distal (>10kb) Multiome | 202 | |
| chr2:119,218,121–119,219,066 | 5.1 kb | Proximal (<10kb) Multiome | 361 | |
| chr2:119,222,190–119,222,633 | 1.2 kb | Proximal (<10kb) | 50 | |
| chr2:119,223,024–119,224,452 | 51 bp | At TSS Multiome | 761 | |
| chr2:119,229,825–119,230,036 | 6.0 kb | Proximal (<10kb) | 53 | |
| chr2:119,366,351–119,367,938 | 143.1 kb | Distal (>10kb) Multiome | 994 | |
| chr2:119,431,298–119,432,803 | 207.9 kb | Distal (>10kb) Multiome | 903 | |
| chr2:119,476,117–119,476,795 | 252.7 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the STEAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.