This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STEAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STEAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STEAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:88,218,838–88,220,775 | 1934.3 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr7:88,758,363–88,760,421 | 1395.0 kb | Distal (>10kb) Multiome HiCAR | 415 | |
| chr7:90,149,543–90,149,721 | 4.7 kb | Proximal (<10kb) | 9 | |
| chr7:90,152,743–90,153,118 | 1.3 kb | Proximal (<10kb) | 63 | |
| chr7:90,153,881–90,154,994 | 59 bp | At TSS Multiome | 605 | |
| chr7:90,210,927–90,212,730 | 57.3 kb | Distal (>10kb) Multiome | 843 | |
| chr7:90,223,993–90,224,776 | 69.9 kb | Distal (>10kb) Multiome | 109 | |
| chr7:90,244,257–90,246,748 | 90.8 kb | Distal (>10kb) Multiome HiCAR | 850 | |
| chr7:90,345,490–90,347,070 | 192.2 kb | Distal (>10kb) Multiome | 940 | |
| chr7:90,403,221–90,404,177 | 249.2 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the STEAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.