Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for STAU2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAU2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAU2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,448,791–73,449,788 | 297.6 kb | Distal (>10kb) Multiome | 239 | |
| chr8:73,745,665–73,747,641 | 170 bp | At TSS Multiome | 863 | |
| chr8:73,747,903–73,748,155 | 1.1 kb | Proximal (<10kb) | 193 | |
| chr8:73,877,680–73,879,555 | 132.1 kb | Distal (>10kb) Multiome | 897 | |
| chr8:73,971,155–73,973,036 | 225.5 kb | Distal (>10kb) Multiome | 889 | |
| chr8:73,975,889–73,976,754 | 229.4 kb | Distal (>10kb) Multiome | 855 |
Genomic view of the STAU2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.