STARD3
StAR related lipid transfer domain containing 3 | MLN64, es64

This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Developmental clusters: GC1
Biological processes 34 terms
cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)cholesterol metabolic process (GO:0008203)cholesterol transfer activity (GO:0120020)cholesterol transfer activity (GO:0120020)cholesterol transport (GO:0030301)cholesterol transport (GO:0030301)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum-endosome membrane contact site (GO:0140284)endoplasmic reticulum-endosome membrane contact site (GO:0140284)endoplasmic reticulum-endosome membrane contact site (GO:0140284)endosome (GO:0005768)endosome (GO:0005768)late endosome (GO:0005770)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)lipid binding (GO:0008289)lipid metabolic process (GO:0006629)lysosomal membrane (GO:0005765)mitochondrial transport (GO:0006839)mitochondrion (GO:0005739)organelle membrane contact site (GO:0044232)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)steroid metabolic process (GO:0008202)steroid metabolic process (GO:0008202)vesicle tethering to endoplasmic reticulum (GO:0099044)vesicle tethering to endoplasmic reticulum (GO:0099044)vesicle tethering to endoplasmic reticulum (GO:0099044)
Expression (TPM)
STARD3 — as a Regulated Gene

TFs regulating STARD3 0 TFs

Transcription factors with Perturb-seq knockdown data for STARD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STARD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to STARD3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STARD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:39,400,997–39,402,766 234.5 kb Distal (>10kb) Multiome 898
chr17:39,450,919–39,451,504 185.8 kb Distal (>10kb) Multiome 722
chr17:39,461,043–39,462,217 175.6 kb Distal (>10kb) Multiome 1026
chr17:39,573,453–39,574,243 63.4 kb Distal (>10kb) Multiome 520
chr17:39,636,769–39,637,600 13 bp At TSS Multiome 853
chr17:39,652,588–39,653,348 15.8 kb Distal (>10kb) Multiome 263
chr17:39,668,234–39,668,690 31.4 kb Distal (>10kb) Multiome 706
chr17:39,687,710–39,688,437 50.9 kb Distal (>10kb) Multiome 800
chr17:39,695,905–39,696,636 59.1 kb Distal (>10kb) Multiome 499
chr17:39,699,516–39,700,527 62.8 kb Distal (>10kb) Multiome 528
chr17:39,730,039–39,730,906 93.4 kb Distal (>10kb) Multiome 886
chr17:39,739,067–39,739,915 102.4 kb Distal (>10kb) Multiome 648
chr17:39,740,384–39,740,910 103.6 kb Distal (>10kb) Multiome 513
chr17:39,753,811–39,754,996 117.2 kb Distal (>10kb) Multiome 1000
chr17:39,926,716–39,928,343 290.6 kb Distal (>10kb) Multiome 942

Genome Browser

Genomic view of the STARD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:39,390,997 – 39,938,343
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact