The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STAM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:151,947,105–151,947,762 | 228.3 kb | Distal (>10kb) Multiome | 177 | |
| chr2:152,042,296–152,043,510 | 132.8 kb | Distal (>10kb) Multiome | 242 | |
| chr2:152,055,231–152,056,165 | 120.1 kb | Distal (>10kb) Multiome | 199 | |
| chr2:152,097,676–152,099,753 | 76.8 kb | Distal (>10kb) Multiome | 496 | |
| chr2:152,175,135–152,176,549 | 53 bp | At TSS Multiome | 1112 | |
| chr2:152,334,897–152,336,898 | 159.5 kb | Distal (>10kb) Multiome | 886 | |
| chr2:152,415,235–152,415,733 | 239.6 kb | Distal (>10kb) Multiome | 256 | |
| chr2:152,452,653–152,454,217 | 277.7 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the STAM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.