This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for STAM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:15,856,555–15,857,325 | 1787.3 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr10:17,379,036–17,380,059 | 264.8 kb | Distal (>10kb) Multiome | 120 | |
| chr10:17,387,758–17,388,950 | 255.9 kb | Distal (>10kb) Multiome | 319 | |
| chr10:17,453,122–17,455,034 | 189.8 kb | Distal (>10kb) Multiome | 584 | |
| chr10:17,616,423–17,618,050 | 26.8 kb | Distal (>10kb) Multiome | 800 | |
| chr10:17,643,443–17,644,922 | 121 bp | At TSS Multiome | 877 | |
| chr10:17,650,742–17,651,323 | 6.5 kb | Proximal (<10kb) | 136 | |
| chr10:17,673,416–17,674,078 | 29.6 kb | Distal (>10kb) Multiome | 368 | |
| chr10:17,836,569–17,837,890 | 192.9 kb | Distal (>10kb) Multiome | 195 | |
| chr10:17,907,502–17,908,396 | 263.8 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the STAM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.