ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ST6GALNAC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST6GALNAC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST6GALNAC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,608,129–127,608,913 | 291.1 kb | Distal (>10kb) Multiome | 700 | |
| chr9:127,611,734–127,612,761 | 287.4 kb | Distal (>10kb) Multiome | 566 | |
| chr9:127,699,155–127,699,632 | 200.1 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 183.8 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 164.3 kb | Distal (>10kb) Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 156.8 kb | Distal (>10kb) Multiome | 367 | |
| chr9:127,754,123–127,755,506 | 144.2 kb | Distal (>10kb) Multiome | 279 | |
| chr9:127,770,807–127,771,925 | 128.1 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 113.0 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 96.7 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 89.7 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 74.0 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 71.0 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 21.8 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 2.1 kb | Proximal (<10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 4 bp | At TSS Multiome | 630 | |
| chr9:127,903,547–127,903,793 | 4.0 kb | Proximal (<10kb) | 488 | |
| chr9:127,916,386–127,917,505 | 17.5 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 27.9 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 31.2 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 38.3 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 56.0 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 81.5 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 134.3 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 135.7 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,066,577–128,068,774 | 167.8 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 198.8 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 218.3 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 228.7 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 260.5 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 292.1 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the ST6GALNAC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.