This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ST6GAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST6GAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST6GAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:186,653,868–186,654,549 | 276.3 kb | Distal (>10kb) Multiome | 163 | |
| chr3:186,772,225–186,772,685 | 158.0 kb | Distal (>10kb) Multiome | 147 | |
| chr3:186,772,788–186,773,308 | 157.5 kb | Distal (>10kb) Multiome | 241 | |
| chr3:186,775,941–186,776,679 | 154.3 kb | Distal (>10kb) Multiome | 161 | |
| chr3:186,782,866–186,784,510 | 146.3 kb | Distal (>10kb) Multiome | 1121 | |
| chr3:186,806,142–186,807,252 | 123.9 kb | Distal (>10kb) Multiome | 877 | |
| chr3:186,824,344–186,826,061 | 104.9 kb | Distal (>10kb) Multiome | 328 | |
| chr3:186,827,252–186,828,058 | 102.9 kb | Distal (>10kb) Multiome | 539 | |
| chr3:186,929,799–186,932,446 | 162 bp | At TSS Multiome | 861 | |
| chr3:186,998,752–186,999,772 | 68.8 kb | Distal (>10kb) Multiome | 215 | |
| chr3:187,025,680–187,026,649 | 95.6 kb | Distal (>10kb) Multiome | 205 | |
| chr3:187,139,092–187,139,958 | 209.1 kb | Distal (>10kb) Multiome | 634 | |
| chr3:187,150,031–187,150,922 | 220.1 kb | Distal (>10kb) Multiome | 66 | |
| chr3:187,164,995–187,165,480 | 234.8 kb | Distal (>10kb) Multiome | 168 | |
| chr3:187,180,878–187,181,558 | 250.7 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the ST6GAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.