The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for ST3GAL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST3GAL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST3GAL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:98,521,861–98,523,430 | 209.5 kb | Distal (>10kb) Multiome | 832 | |
| chr3:98,592,698–98,594,265 | 138.7 kb | Distal (>10kb) Multiome | 864 | |
| chr3:98,722,089–98,722,808 | 9.6 kb | Proximal (<10kb) | 108 | |
| chr3:98,732,084–98,734,092 | 25 bp | At TSS Multiome | 726 | |
| chr3:98,893,597–98,894,718 | 161.5 kb | Distal (>10kb) Multiome | 237 | |
| chr3:98,900,504–98,902,679 | 169.4 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the ST3GAL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.