The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for SSB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:169,479,264–169,479,982 | 319.3 kb | Distal (>10kb) Multiome HiCAR | 907 | |
| chr2:169,573,179–169,574,073 | 225.0 kb | Distal (>10kb) Multiome | 834 | |
| chr2:169,584,221–169,584,891 | 214.4 kb | Distal (>10kb) Multiome | 994 | |
| chr2:169,694,097–169,694,854 | 104.4 kb | Distal (>10kb) Multiome | 898 | |
| chr2:169,733,252–169,734,532 | 64.9 kb | Distal (>10kb) Multiome | 735 | |
| chr2:169,789,706–169,790,238 | 8.9 kb | Proximal (<10kb) Multiome | 539 | |
| chr2:169,798,658–169,799,453 | 45 bp | At TSS Multiome | 794 | |
| chr2:169,824,413–169,825,252 | 26.1 kb | Distal (>10kb) Multiome | 946 | |
| chr2:169,827,076–169,828,199 | 28.6 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the SSB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.