SRSF8

serine and arginine rich splicing factor 8 | SRP46, SFRS2B

This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Member of: DE-7

Biological processes 10 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)mRNA binding (GO:0003729)nuclear speck (GO:0016607)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)

Expression (TPM)

TFs regulating SRSF8 0 TFs

Transcription factors with Perturb-seq knockdown data for SRSF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SRSF8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:94,766,900–94,769,104	298.6 kb	Distal (>10kb) Multiome	701
chr11:94,973,096–94,974,006	93.3 kb	Distal (>10kb) Multiome	740
chr11:95,066,821–95,068,191	572 bp	At TSS Multiome	721
chr11:95,068,617–95,068,803	1.7 kb	Proximal (<10kb)	391
chr11:95,069,561–95,070,184	2.6 kb	Proximal (<10kb)	239
chr11:95,089,389–95,090,696	22.9 kb	Distal (>10kb) Multiome	660
chr11:95,107,207–95,108,126	40.7 kb	Distal (>10kb) Multiome	232
chr11:95,149,652–95,152,295	84.6 kb	Distal (>10kb) Multiome	685
chr11:95,229,933–95,232,611	164.4 kb	Distal (>10kb) Multiome	696

Genome Browser

Genomic view of the SRSF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.