This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for SRSF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:68,231,101–68,233,483 | 1973.1 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr1:68,496,039–68,497,758 | 1708.5 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr1:70,204,918–70,206,272 | 22 bp | At TSS Multiome | 947 | |
| chr1:70,220,557–70,220,861 | 517 bp | At TSS | 49 | |
| chr1:70,220,975–70,221,995 | 15.8 kb | Distal (>10kb) Multiome | 912 | |
| chr1:70,353,684–70,355,124 | 149.0 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:70,410,268–70,411,834 | 205.4 kb | Distal (>10kb) Multiome | 925 |
Genomic view of the SRSF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.