Predicted to enable mRNA binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRRM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRRM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRRM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,914,282–75,915,911 | 286.8 kb | Distal (>10kb) Multiome | 1021 | |
| chr7:75,993,473–75,995,401 | 207.2 kb | Distal (>10kb) Multiome | 873 | |
| chr7:76,047,582–76,048,952 | 153.8 kb | Distal (>10kb) Multiome | 920 | |
| chr7:76,073,173–76,073,663 | 128.4 kb | Distal (>10kb) Multiome | 100 | |
| chr7:76,163,449–76,164,544 | 37.9 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 35.2 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 23.6 kb | Distal (>10kb) Multiome | 670 | |
| chr7:76,191,910–76,192,159 | 9.7 kb | Proximal (<10kb) | 149 | |
| chr7:76,201,356–76,202,307 | 78 bp | At TSS Multiome HiCAR | 937 | |
| chr7:76,234,695–76,235,681 | 33.5 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr7:76,259,707–76,261,052 | 58.5 kb | Distal (>10kb) Multiome HiCAR | 332 | |
| chr7:76,267,044–76,267,853 | 65.5 kb | Distal (>10kb) Multiome | 211 | |
| chr7:76,282,299–76,283,220 | 80.7 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr7:76,291,428–76,292,275 | 90.0 kb | Distal (>10kb) Multiome HiCAR | 767 | |
| chr7:76,302,207–76,304,173 | 101.8 kb | Distal (>10kb) Multiome | 943 | |
| chr7:76,314,028–76,314,686 | 112.5 kb | Distal (>10kb) Multiome | 715 | |
| chr7:76,317,523–76,319,173 | 116.3 kb | Distal (>10kb) Multiome | 840 | |
| chr7:76,358,237–76,359,989 | 157.4 kb | Distal (>10kb) Multiome | 1036 | |
| chr7:76,379,650–76,380,602 | 178.1 kb | Distal (>10kb) Multiome | 853 | |
| chr7:76,392,882–76,394,121 | 191.4 kb | Distal (>10kb) Multiome | 932 | |
| chr7:76,395,928–76,396,741 | 194.3 kb | Distal (>10kb) Multiome | 152 | |
| chr7:76,397,187–76,397,970 | 195.7 kb | Distal (>10kb) Multiome | 496 | |
| chr7:76,409,261–76,409,956 | 207.9 kb | Distal (>10kb) Multiome | 281 | |
| chr7:76,510,075–76,510,721 | 308.5 kb | Distal (>10kb) Multiome | 201 | |
| chr7:76,548,975–76,549,826 | 347.4 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the SRRM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.