Transcription factors with Perturb-seq knockdown data for SRRM2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRRM2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRRM2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,459,524–2,460,612 | 292.5 kb | Distal (>10kb) Multiome | 670 | |
| chr16:2,467,565–2,468,324 | 284.8 kb | Distal (>10kb) Multiome | 450 | |
| chr16:2,470,913–2,472,223 | 281.3 kb | Distal (>10kb) Multiome | 427 | |
| chr16:2,473,455–2,476,127 | 277.4 kb | Distal (>10kb) Multiome | 719 | |
| chr16:2,501,124–2,501,877 | 251.1 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,513,006–2,514,809 | 238.8 kb | Distal (>10kb) Multiome | 818 | |
| chr16:2,520,064–2,520,618 | 232.2 kb | Distal (>10kb) Multiome | 624 | |
| chr16:2,531,456–2,533,080 | 220.5 kb | Distal (>10kb) Multiome | 883 | |
| chr16:2,537,433–2,538,433 | 214.7 kb | Distal (>10kb) Multiome | 498 | |
| chr16:2,603,176–2,603,939 | 149.2 kb | Distal (>10kb) Multiome | 1066 | |
| chr16:2,673,059–2,673,910 | 79.1 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 70.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 31.3 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 72 bp | At TSS Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 24.7 kb | Distal (>10kb) Multiome | 828 | |
| chr16:2,867,958–2,868,665 | 115.8 kb | Distal (>10kb) Multiome | 960 | |
| chr16:2,882,042–2,883,813 | 130.4 kb | Distal (>10kb) Multiome | 838 | |
| chr16:2,904,002–2,906,321 | 151.7 kb | Distal (>10kb) Multiome | 994 | |
| chr16:2,911,480–2,912,624 | 159.3 kb | Distal (>10kb) Multiome | 784 | |
| chr16:2,963,159–2,965,475 | 211.4 kb | Distal (>10kb) Multiome | 628 | |
| chr16:2,968,641–2,970,561 | 216.6 kb | Distal (>10kb) Multiome | 1039 | |
| chr16:2,979,651–2,981,140 | 227.9 kb | Distal (>10kb) Multiome | 795 | |
| chr16:2,981,390–2,982,257 | 229.2 kb | Distal (>10kb) Multiome | 460 | |
| chr16:3,003,612–3,004,589 | 251.4 kb | Distal (>10kb) Multiome | 652 | |
| chr16:3,007,583–3,008,956 | 255.9 kb | Distal (>10kb) Multiome | 514 | |
| chr16:3,009,722–3,010,376 | 257.5 kb | Distal (>10kb) Multiome | 395 | |
| chr16:3,017,242–3,018,799 | 265.6 kb | Distal (>10kb) Multiome | 451 | |
| chr16:3,019,969–3,022,268 | 267.7 kb | Distal (>10kb) Multiome | 963 | |
| chr16:3,022,890–3,024,532 | 271.6 kb | Distal (>10kb) Multiome | 933 | |
| chr16:3,027,854–3,029,038 | 275.7 kb | Distal (>10kb) Multiome | 546 | |
| chr16:3,036,222–3,037,148 | 284.3 kb | Distal (>10kb) Multiome | 256 | |
| chr16:3,045,413–3,047,408 | 293.6 kb | Distal (>10kb) Multiome | 510 |
Genomic view of the SRRM2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.